Speaker: Professor Motohiro Nishida.
Title: "Zinc as a cardiotonic mediator".
Impaired baroreflex-dependent cardiac contraction (positive inotropy) through sympathetic nerve activation is a major cause for bad prognosis of heart failure. We found that a local Zn2+ influx through transient receptor potential canonical (TRPC) 6 channel potentiates (3 -adrenoceptor ((3AR) -stimulated cardiac positive inotropy in mice. TRPC6-mediated Zn2+ influx boosts a1 adrenergic receptor (AR)-stimulated (3AR/G5 -dependent signaling in rat cardiomyocytes by inhibiting (3 -arrestin-mediated (3AR internalization. I will introduce that TRPC6-mediated Zn2+ influx with a1AR stimulation enhances baroreflex-induced positive inotropy which may be a new therapeutic strategy for chronic heart failure.
Zoom meeting details are:
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Meeting ID: 878 3737 1158
Contact: Leigh Ackland; Meeting organizer of ISZB-Asia/Oceania: leigh.
To be held on January 24, 2023.
5 pm Australia/Melbourne time (this is 6pm AEDT Australian Daylight Saving Time. Zoom is using AEST so log in at 6pm, not 5pm)
4 pm Japan/Tokyo time
3 pm China/Beijing time
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7 pm New Zealand time (this is 7 pm New Zealand Standard Time but 8 pm Daylight Saving Time. Zoom is using New Zealand Standard Time so log in at 8 pm, not 7 pm)