A 3-year Medical Research Council UK funded position is available for a highly-motivated, ambitious candidate with strong interest in host-pathogen interaction to join the Microbial Pathogenesis research team of Dr. Gunnar Schroeder at the Centre for Experimental Medicine (CEM).
The successful candidate will drive an exciting research programme and use microbiological, cell biological and biochemical methods combined with cutting-edge imaging and proteomics analysis to elucidate new molecular mechanisms of host (macrophages/protozoa) subversion by the facultative intracellular human pathogen Legionella pneumophila, the causative agent of Legionnaires’ disease.
The Schroeder Team is based in the brand-new Wellcome-Wolfson Building providing state-of-the-art labs and research facilities. The successful candidate will be part of a dynamic and collaborative team, a vibrant, international postdoc community and have access to personal development opportunities.
The post is a senior role in the team and as such, successful applicants will have responsibilities in independent research, supervision, planning, day-to-day lab management, collaborations and outreach. The post is suited to an organised, productive and communicative individual, preferably with previous postdoctoral experience in studying the molecular mechanisms of host-pathogen interactions.
Application deadline is the 7th of February.
More details are available here.
The BioSys-Biological Systems, Functional & Integrative Genomics PhD Programme (PhD in Biology/Biochemistry) has opened its 2018 edition project calls (https://biosyssite.wordpress.com/) , with several projects available.
APPLICATION DEADLINE: 24th October 2017
Specifically, we call your attention to the following project on Alzheimer’s Disease pathomechanisms, involving our laboratories in Lisbon (Portugal) and Limerick (Ireland)
The role of secondary modification of S100B in protein aggregation and its influence on Alzheimer’s disease pathology.
Keywords: AD; Protein aggregation, trace metals; inflammation; animal models; structural biophysics; metal-binding proteins; neuronal cell cultures; fluorescence bioimaging; biochemistry; neurodegeneration
In this project, we want to investigate the interrelationship between the S100B pro-inflammatory cytokine, trace metal homeostasis and protein aggregation in a physiological context, and in the background of Alzheimer’s disease (AD). The project will combine in vitro and in vivo approaches and will be developed jointly at the University of Lisbon (Portugal) and University of Limerick (Ireland) under the joint supervision of active supervisors in dynamic laboratories which with an established collaborative track record. Selected candidate will be awarded a stipend for the duration of the PhD.
Project Supervisors: Cláudio M. Gomes (Lisbon) and Andreas Grabrucker (Limerick)
Cláudio M. Gomes (BioISI/FCUL, Lisbon, Portugal)
Head of the Protein Folding and Misfolding Laboratory
Andreas Grabrucker (University of Limerick / Bernal Institute, Limerick, Ireland)
Head of the Cellular Neurobiology & Neuro-Nanotechnology Laboratory
Further information anon applications and on the BioSys PhD programme
One position available for a postdoctoral fellow in my laboratory with background in Immunology and Infectious diseases (preferably fungal / bacterial immunology) in the Dept. of Internal Medicine at University of Cincinnati. Primary goal is to reveal novel roles for metalloproteins in immunological processes and inflammation. Project will involve studying novel pathways that regulate fundamental behaviors of immune cells, responses to fungal infection and inflammatory processes that influence antimicrobial defense mechanisms. Candidate will have access to state-of-the-art facilities available at both UC and CCHMC and will have the opportunity to work in a collaborative research environment.
Candidate must have a Ph.D or MD/Ph.D degree in life sciences. Knowledge of innate and adaptive immunity to infections is required. Extensive prior experience with in vitro and in vivo approaches (mouse models), molecular biology, cell culture, immunological techniques such as flow cytometry is expected. Knowledge and hands-on experience with CRISPR is desired. Successful candidate must have proven track record of publications, be highly productive, self-motivated, independent, willing to incorporate new ideas and techniques and have strong verbal and written scientific communication skills.
Interested candidates may contact Kavitha.Subramanian@uc.edu with CV and specific research interests.