PhD Scholarship in Waterford Institute of Technology Ireland

The School of Health Sciences and the Nutrition Research Centre Ireland in the Waterford Institute of Technology in Ireland are offering a PhD Scholarship in “Enhancing the bioavailability of macular carotenoids from supplement formulations”. Applications close April 24th 2017. For more information please see the following link:

https://www.wit.ie/images/uploads/Current_Students_PDF/WIT_Industry-led_PhD_Scholarship_John_Nolan_with_Industrial_Organica_2.pdf

 

Kind Regards, BON Conference Committee

Research Fellow in Metals Analysis and Bioimaging

We are looking to recruit an experienced and motivated Research Fellow to play a central role in developing and maintaining the new “London Metallomics Facility”. This facility is funded by the Wellcome Trust and this role will be crucial in providing scientific support and also networking and promoting the centre. Click here for more details.

PhD studentship

PhD studentship “Identifying regulators of tissue regeneration by in vivo imaging in the zebrafish”

 

Supervisory team: Dr. Robert Knight (robert.knight@kcl.ac.uk), Prof. Christer Hogstrand (christer.hogstrand@kcl.ac.uk)

 

Sponsor: NC3Rs

 

Eligibility Home/EU (residency rules apply)

 

Funding available tuition fees £4121 per year, stipend of £16,296 per year, duration: 3 years.

 

Abstract

This proposal aims to use a zebrafish model of muscle regeneration in order to identify the signals between muscle stem cells (muSCs) and inflammatory cells. The purpose is to determine which signals regulate their interactions during regeneration and so control muscle repair. Specific Aims to be tested include:

  1. determine how key pro- and anti-regenerative signals regulate muSCs and mø responses to tissue injury
  2. identify candidate signalling pathways controlling muSCs and mø interactions during muscle regeneration
  3. functionally test the role of candidate cell signalling pathways in controlling muSC responses to injury

To address these aims we will use transgenic zebrafish for gene over-expression and visualisation of cells during regeneration. Imaging of stem cell and macrophage responses to injury will be performed by confocal and multiphoton microscopy. To identify complementary signals and receptors expressed between muSCs and inflammatory cells, gene expression profiling will be performed on cells isolated by flow cytometry using RNA sequencing. Candidate secreted proteins and their respective receptors that could act to signal between muSCs and inflammatory cells will be identified using computational analyses of sequencing data. These candidate molecules will then be tested in vivo by over-expression under the control of tissue specific promoters and their affects measured by live cell imaging.

 

Deadline for applications: 31st Jan 2017

Expected start date: 1 October 2017