The BioSys-Biological Systems, Functional & Integrative Genomics PhD Programme (PhD in Biology/Biochemistry) has opened its 2018 edition project calls (https://biosyssite.wordpress.com/) , with several projects available.
APPLICATION DEADLINE: 24th October 2017
Specifically, we call your attention to the following project on Alzheimer’s Disease pathomechanisms, involving our laboratories in Lisbon (Portugal) and Limerick (Ireland)
The role of secondary modification of S100B in protein aggregation and its influence on Alzheimer’s disease pathology.
Keywords: AD; Protein aggregation, trace metals; inflammation; animal models; structural biophysics; metal-binding proteins; neuronal cell cultures; fluorescence bioimaging; biochemistry; neurodegeneration
In this project, we want to investigate the interrelationship between the S100B pro-inflammatory cytokine, trace metal homeostasis and protein aggregation in a physiological context, and in the background of Alzheimer’s disease (AD). The project will combine in vitro and in vivo approaches and will be developed jointly at the University of Lisbon (Portugal) and University of Limerick (Ireland) under the joint supervision of active supervisors in dynamic laboratories which with an established collaborative track record. Selected candidate will be awarded a stipend for the duration of the PhD.
Project Supervisors: Cláudio M. Gomes (Lisbon) and Andreas Grabrucker (Limerick)
Cláudio M. Gomes (BioISI/FCUL, Lisbon, Portugal)
Head of the Protein Folding and Misfolding Laboratory
Andreas Grabrucker (University of Limerick / Bernal Institute, Limerick, Ireland)
Head of the Cellular Neurobiology & Neuro-Nanotechnology Laboratory
Further information anon applications and on the BioSys PhD programme
Queen’s University Belfast’s Dr Imre Lengyel discusses new research which could pave the way to earlier treatment strategies for age-related macular degeneration.
The leading cause of sight loss in development countries, age-related macular degeneration (AMD) is roughly twice as common as Alzheimer’s among older people – and growing. By 2020, it is projected to affect some 196 million people, rising to a massive 288 million by 2040. But while AMD can now be treated with an injection of anti-vascular endothelial growth factor (VEGF), there is currently no treatment available for the most common dry form of AMD.
More information can be found here.
Project ID: 734931
Funded under: H2020-EU.1.3.3. – Stimulating innovation by means of cross-fertilisation of knowledge
Total cost: EUR 864 000
Coordinated in: France
Topic(s): MSCA-RISE-2016 – Research and Innovation Staff Exchange
Call for proposal: H2020-MSCA-RISE-2016 See other projects for this call
Funding scheme: MSCA-RISE – Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
Increased longevity with a high quality of life is desirable not only for personal life-satisfaction but also for reducing healthcare costs and for increasing the socioeconomic contributions of individuals in countries with ageing population demographics. Lifelong lifestyle has an important impact on health status in older age and adequate nutrition plays a key role in maintaining cellular functions within normal limits. Microelements such as zinc (Zn) and copper (Cu) are essential for life and are involved in the normal functioning of thousands of proteins. The dysregulation of these metals leads to perturbed homeostasis, disease and diminished quality of life. In this study, the molecular mechanisms by which ageing
affects Zn and Cu absorption and excretion will be determined, and the consequent impact on metal flux and transport kinetics will be expressed by mathematical modelling. The project output will include a predictive model for the impact of ageing on Zn and Cu homeostasis, informing intervention with dietary advice or supplementation to improve longevity. The consortium combines intersectoral and interdisciplinary expertise from 3 EU and 2 partner countries with established links and clear potential for knowledge exchange and transfer of skills.
The consortium objectives are:
1. To determine the impact of dietary Zn and Cu on the microbiota and also age-related changes in the microbiota composition on the absorption of Zn and Cu.
2. To understand the influence of senescence on the regulation of Zn and Cu flux into and out of key cells controlling their homeostasis (gut mucosal cells, pancreatic acinar cells and hepatocytes) and its impact on the expression of related genes such as transporters.
3. To determine how senescence affects the transporter proteins, channels and chaperones involved in regulating Zn and Cu trafficking through the key absorptive and excretory cells affecting body metal homeostasis.
Prof. Irina Korichneva (UPJV, Amiens, France)
Prof. John H. Beattie (Rowett Institute, Aberdeen, UK)
Dr Vladimir Fetyukhin (IFLab, Kiev, Ukraine)
Prof. Miguel Arendondo (INTA, Santiago, Chile)
Prof. Marvin Reid (UWI, Kingston, Jamaica)